[Effects of verapamil and gynipral on the uterine contractile activity in rats]

O V Kaplenko; V V Korkhov; E A Lesik

[Effects of verapamil and gynipral on the uterine contractile activity in rats]

Eksp Klin Farmakol. 2000 Nov-Dec;63(6):28-9.

[Article in Russian]

Authors

O V Kaplenko¹, V V Korkhov, E A Lesik

Affiliation

¹ Laboratory of Pharmacology, Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, Mendeleevskaya Liniya 3, St. Petersburg, 199034 Russia.

PMID: 11202506

Abstract

Verapamil and gynipral administered to pregnant rats in doses on a clinical level suppress the uterine contractions, which is manifested by a decrease in the amplitude and frequency of the biopotential. The joint administration of gynipral and verapamil (in half doses) resulted in a pronounced tocolytic effect.

Publication types

English Abstract

MeSH terms

Adrenergic beta-Agonists / pharmacology*
Animals
Calcium Channel Blockers / pharmacology*
Drug Synergism
Female
Hexoprenaline / pharmacology*
Myometrium / physiology
Pregnancy
Rats
Rats, Wistar
Tocolytic Agents / pharmacology*
Uterine Contraction / drug effects*
Verapamil / pharmacology*

Substances

Adrenergic beta-Agonists
Calcium Channel Blockers
Tocolytic Agents
Verapamil
Hexoprenaline